ANTICORPS CONJUGUÉS
> Nouveaux conjugués anticorps-médicament et leur utilisation en thérapie. Joubert, N ; Viaud-Massuard, MC ; Respaud, R. Patent. WO2015004400A1.
> Antibody–drug conjugates: historical developments and mechanisms of action. Joubert, N.; Viaud-Massuard, MC ; Optim ADC Target Del Ther 2015, pp 6-21.
> Increment in drug loading on an antibodydrug conjugate increases its binding to the human neonatal Fc receptor in vitro. Brachet, G. & al. Mol. Pharmaceut. 2016, 13, 1405-1412.
> A New Chemical Platform for the Modular Construction of Homogeneous Antibody-Drug Conjugates. N Joubert, C Martin, S Letast, MC Viaud-Massuard. Magic Bullet: 5th Int. CeBiTec Research Conference: Drug Conjugates for Directed Therapy, Bielefeld, Allemagne, 20-23 Septembre 2015.
> New Chemical Tools for the Modular Construction of Homogeneous Antibody-Drug Conjugates. C Martin, & al. XXIIème Journée Jeunes Chercheurs, Paris, 4 au 6 Février 2015. PRIX Am Chem Society et PRIX Société Chimique de France.
CHIMIE MÉDICINALE
> Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors Baltus, CB.& al. Eur. J. Med. Chem. 2016, 108, 701-719.
> Palladium-catalyzed amination of N-free 2-chloro-7-azaindo Plas, A.; Martin, C.; Joubert, N.; Viaud-Massuard, M.-C. Org. Lett. 2015, 17, 4710-4713.
> Rhodium-catalyzed 1,4-addition of arylboronic acids to 3-benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-one derivatives. Croix, C.; Prie, G.; Chaulet, C.; Viaud-Massuard, M.-C. J. Org. Chem. 2015, 80, 3264-3269.
> Synthesis of novel 2,4-disubstituted 3H-pyrido[3,2-e][1,4]diazepin-5-ones and 2,4-disubstituted 3H-pyrido[2,3-e][1,4]diazepin-5-ones derivatives via regioselective thionation and nucleophilic substitutions reactions. El Bouakher, A.; Prie, G.; Aadil, M.; Akssira, M.; Viaud-Massuard, M.-C. Tetrahedron 2013, 69, 5086-5091.
> Olefin cross-metathesis/Suzuki-Miyaura reactions on vinylphenylboronic acid pinacol esters. Baltus, C. B.; Chuckowree, I. S.; Press, N. J.; Day, I. J.; Coles, S. J.; Tizzard, G. J.; Spencer, J. Tetrahedron Lett. 2013, 54, 1211-1217.
> A selective reversible azapeptide inhibitor of human neutrophil proteinase 3 derived from a high affinity FRET substrate. Epinette, C & al Biochem. Pharmacol. 2012, 83, 788-796.
> Efficient and general protocol for Sonogashira cross-coupling reactions of maleimides. Souffrin, A.; Croix, C.; Viaud-Massuard, M.-C. Eur. J. Org. Chem. 2012, 2012, 2499-2502.
> Microwave-mediated synthesis of an arylboronate library. Spencer, J.; Baltus, C. B.; Patel, H.; Press, N. J.; Callear, S. K.; Male, L.; Coles, S. J. ACS Comb. Sci. 2011, 13, 24-31.
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